Observe Closely (1)lumefantrine will lessen the level or result of exemestane by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. For patients acquiring exemestane with a strong CYP3A4 inducer the encouraged dose of exemestane is 50 mg daily following a meal.larotrectinib will improve the level or outcome of exeme